【摘 要】
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Background, Motivation and Objective According to the postulated "response to injury theory", atherosclerosis develops as a result of repetitive injury and ongoing inflammatory process of the inner ar
【机 构】
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The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi'an Jiaotong U
论文部分内容阅读
Background, Motivation and Objective According to the postulated "response to injury theory", atherosclerosis develops as a result of repetitive injury and ongoing inflammatory process of the inner arterial wall of large and medium-size arteries. Mechanical arterial balloon injury combined with hypercholesterolemia is one of the most widely employed methods to induce atherosclerosis in animal models. However, the balloon injury operation is complicated and the plaque site is unpredictable and difficult to control. It is reported that some application of ultrasound (US) to microvessels that contained microbubbles can result in endothelial cells damage and arteries injury. Thus we propose that microbubble enhanced US cavitation would induce controllable local artery wall injury and then could be an alternative method to the balloon injury for inducing a localized eccentric vulnerable plaque at desired specific site.
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