Drug Delivery Is Promoted by Low-Intensity Ultrasound Due to an Increase in Clathrin-Mediated Endocy

来源 :2015两岸超声技术与医学研讨会 | 被引量 : 0次 | 上传用户:zzm0901
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Background, Motivation and Objective Ultrasound (US) mediated drug delivery is a field with promising results although the exact mechanisms behind intracellular delivery of drugs remain to be elucidated. Most of the studies used drug carriers and cavitation to enhance drug uptake in tumor cells. However, cavitation could induce cell lysis and remain difficult to control and predict in vivo. In this study, low intensity ultrasound with proper sonication parameters were used to induce clathrin-mediated endocytosis and to force the penetration of a bisphosphonate (Zoledronic acid: ZOL) into tumor cells.
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