【摘 要】
：
G蛋白偶联受体及其下游信号通路调节离子通道的开放,尤其是TRP通道的活力引起人们广泛关注.我们最近的研究发现,一种黏附类G蛋白偶联受体可以通过自剪切的方式水解为Alpha和B
【机 构】
：
山东大学医学院生理学系,济南,山东250012山东大学医学院生物化学与分子生物学系,济南,山东250012
【出 处】
：
The 10th Chinese Symposium on Calcium Signaling(第十届全国钙信号和细胞功
论文部分内容阅读
G蛋白偶联受体及其下游信号通路调节离子通道的开放,尤其是TRP通道的活力引起人们广泛关注.我们最近的研究发现,一种黏附类G蛋白偶联受体可以通过自剪切的方式水解为Alpha和Beta两种亚基.该受体的Alpha和Beta两种亚基分别介导独立的信号途径.其Beta亚基在自切割后,可独立介导G蛋白偶联的信号途径和Arrestin的招募工作,并且该受体组成活力可以激活MCOLN通道,调节细胞内钙离子水平,并对细胞命运进行调控.进一步,我们应用分子生物学和细胞生物学手段阐明了此黏附类G蛋白偶联受体调控TRP通道的机制.
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