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Aim: To study the effects of lignans from Eucommia ulmoides on the proliferation in rat mesangial cell induced by Ang Ⅱ, providing theoretical basis for the application of lignans from Eucommia ulmoides in renoprotection.Methods: Rat glomerular mesangial cell (HBZY-1) were cultured in vitro and divided into 5 groups: control group, Ang Ⅱ group (10-8 mol/L Ang Ⅱ), low concentration lignans group (10-8 mol/L Ang Ⅱ+20 mg/L lignans), middle concentration lignans group (10-8 mol/L Ang Ⅱ+40 mg/L lignans), high concentration lignans group (10-8 mol/L Ang Ⅱ+80 mg/L lignans).