论文部分内容阅读
G-quadruplex is formed in specific G-rich sequences such as telomere 3-overhang and the promoter of oncogenes.
Design,synthesis and anticancer activity of 1,8-naphthalimide-uridine conjugates by targeting telome
【摘 要】
：
G-quadruplex is formed in specific G-rich sequences such as telomere 3-overhang and the promoter of oncogenes.
【机 构】
：
Lab of Chemical Biology and Molecular Drug Design,Dept of Pharmacy,College of Pharmaceutical Science
【出 处】
：
中国化学会第十届全国化学生物学学术会议
【发表日期】
：
2017年10期
其他文献
The appearance of antibiotic resistance caused by metallo-β-lactamases(MβLs)is a global public health threat due to their rapid spread.
Non-alcoholic fatty liver disease(NAFLD)is the hepatic manifestation of obesity and metabolic syndrome,which encompasses a histological spectrum ranging from simple steatosis to nonalcoholic steatohep
Protective effects of Arbutin against Rotenone-induced oxidative stress through AMPK-autophagy relat
Arbutin(Arb),a natural polyphenol extracted from various medicinal plants,shows significant antioxidant activity.
Aminoacyl-tRNA synthetases(aaRSs)catalyze the ligation of amino acids to cognate tRNAs.
会议
By using β-glucuronidase enzyme,microbiota in gastrointestinal(GI)scavenge sugar from glucuronidated compounds as a source of carbon,resulting in activation of drugs from its non-toxic form to toxic c
Phenazine-1-carboxylic acid(PCA)as a natural product widely exists in microbial metabolites of Pseudomonads and Streptomycetes and has been registered for the fungicide against rice sheath blight in C
Many reported aptamers are G-rich oligonucleotides(GROs),which bind their targets based on the G-quadruplex structures.
Human islet amyloid polypeptide(hIAPP)is synthesized by islets beta cell of langerhans,and consists of 37 amino acids.
MSCs induce the epithelial-mesenchymal transition in A549 cells through AKT/GSK-3β/β-catenin pathway
Mesenchymal stem cells(MSCs)are attractive candidates for clinical therapeutic applications.However,the effect and its underlying mechanisms of MSCs in lung cancer remain unclear.
Allatostatins(ASTs),a family of insect neuropeptide,can inhibit juvenile hormone(JH)biosynthesis by the corpora allata(CA)in Diploptera punctata,and therefore be regarded as the potential leads for th