Large integral aluminum panels are the main structure parts of the modern aerospace equipment.Generally, these panels are manufactured by autoclave age forming process (AAF).However, during AAF, the structure of mold, shape of panel and autoclave characteristics (air speed, heating rate and pressure) lead to the uneven temperature distribution in the panel, affecting the quality of the product.Temperature filed of a large aluminum panel with the dimension of 2500 × 1300 × 17mm3, formed under a large frame mold with the radius of 1425 mm, was simulation studied by computational fluid dynamics (CFD) model.The effect of air speed (V), heating rate (H) and pressure (P) on panels temperature field are investigated.It showed that increasing the air speed helps to improve the temperature uniformity of the panel, while raising the heating rate and pressure have the opposite effects.Additionally, the interaction of the autoclave characteristics has a great effect on the panels temperature field.It is found that the combination of the air speed and pressure (V&P) has the biggest effect on the maximum temperature difference (TDmax) of the panel.The magnitude of effects on the panels TDmax correspond to a sequence of V&P > H > V > P > H&V > H&P.