Bioinformatic studies of protein post-translational modifications in the regulation of autophagy and

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  Background: Post-translational modifications (PTMs) play an important role in the regulation of various biological processes,such as transcriptional regulation,signal transduction,cell cycle and cell death.Autophagy is a highly conserved process for degrading cytoplasmic contents,determines cell survival or death,and regulates the cellular homeostasis.Besides core ATG proteins,a large number of regulators together with various PTMs are also involved in autophagy.In this work,the proteins and PTMs in autophagy and cell death pathways were systematically studied.
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