The brain functional and structural mechanism in coal mining survivors with PTSD after two and ten m

来源 :中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the | 被引量 : 0次 | 上传用户:hexqi666
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Objective We sought to characterize the brain responses and structure of patients with acute severe post traumatic stress disorder (PTSD),and investigate the neurocircuit of PTSD.All subjects would be reevaluated at ten months after the coal mining accident for the longitudinal observations.Methods Twenty four individuals with acute severe PTSD resulting from the mining accident and 24 subjects exposed to the mining accident without PTSD underwent functional magnetic resonance imaging (fMRI) while performing the emotional counting stroop,the symptom provocation and trauma related short-term memory recall paradigms.All three functional tasks were block designs.
其他文献
Objective Tight junction (TJ) is an important structural and functional basis of maintaining blood-brain barrier (BBB) integrity.Bradykinin (BK) has been shown to selectively open blood-tumor barrier
Objective Voltage-gated sodium charmels play critical role in the electrical excitability of the brain.Of the known eleven sodium channel genes,four are broadly expressed throughout the central nervou
海马与学习、情绪、记忆等多种神经活动有关,应激能引起海马细胞受损,慢性应激选择性损害海马CA3区神经元,寻找海马细胞保护方法有重要意义。睾丸支持细胞可分泌多种生长因子,可能可以促进海马细胞的贴壁及生长。方法 新生SD乳鼠(出生48 h以内)的海马细胞分离培养,12-16天SD大鼠支持细胞分离培养,分为单纯DMEM组、支持细胞培养液组(SCM)、支持细胞直接共培养组,分别培养24 h、48 h、72
Purpose To investigate the mouse retinal structure during postnatal development with some antibodies specific for glial fibrillary acidic protein (GFAP),Vimentin which were considered as glial cells s
Purpose The electroporation of mouse retinal ganglion cells (RGCs) is not efficient after birth,as transfection of the differentiated neurons is much difficult than the newly born cells or the precurs
目的 观察当归提取物AS-A、AS-B、AS-C、AS-D、AS-E、AS-F、AS-G和AS-B-1对PC12细胞生长分化的影响和对PC12细胞缺氧损伤的保护作用.方法 实验分为空白组、NGF组和给药组.NGF组作为阳性对照,终浓度为20 ng/mL,给药各组在缺氧前24 h分别按25 μg/mL、50 μg/mL和100 μg/mL浓度加入当归不同提取物.将正常培养8天的细胞,移置恒温(37℃
目的 NB-3是1996年发现的神经黏附分子,属于免疫球蛋白超家族中Contactin/F3亚家族中的成员,在神经轴突导向和神经发育中具有重要作用.本实验检测了NB-3在小鼠大脑组织中不同时期的表达情况.方法 (1)主要采用现有的NB-3基因敲除的小鼠即胚胎18天(E18)的NB-3(+/-)胎鼠和8-10周的NB-3(+/-)成鼠的大脑组织,采用X-gal染色的方法检测LacZ基因产物β-半乳糖
目的 观察刺五加(Acanthopanax senticosus)注射液对小鼠密闭缺氧和人脐静脉内皮细胞(ECV304)常压缺氧的保护作用.方法 以KM清洁级雄性小白鼠和ECV304为研究对象,通过小鼠密闭缺氧,记录刺五加高(25 ml/kg)低(12.5 ml/kg)剂量组小鼠因缺氧而死亡的时间;细胞培养,MTT法检测刺五加高(100 μL/mL)低(50 μL/mL)剂量组作用48 h后波长4
目的 利用高场强磁共振质子波谱(1H-nuclear magnetic resonance spectroscopy,1H-MRS)技术,在急性脑梗塞实验模型中研究血管内皮生长因子(Vascular endothelial growth factor,VEGF)介导的脑保护作用及其机制.方法 采用大脑中动脉线栓模型,采用VEGF干预,生理盐水对照,应用1H-MRS研究急性脑缺血后兴趣区内以氮-乙酰
Internalization and sorting of agonist-stimulated receptors between divergent recycling and degradative membrane pathway are critical events determining the functional consequences of p-opioid recepto