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DNA methylation, Histone methylation and acetylation within certain stages are crucial during mammalian development.As a key enzymes for active DNA demethylation, Tet (ten-eleven translocation) protein 1 modulates DNA methylation and gene transcription via hydroxylation of5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC).Moreover, Tet1 participates in Histone modification via binding to gene promoters or forming compound with other proteins to drive the dynamic of epigenetic modification.