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Functional wound dressing has provided new challenges for researchers who focus on burn to improve skin graft quality, reduce scarring, and develop a pluristratified dermal or epidermal construct of a burn wound.This study aimed to investigate the effect of a silk fibroin/gelatin (SF/GT) electrospunnanofibrous dressing loaded with Astragaloside ⅣV (AS) on deep partial-thickness burn wound.