Glycosylation affects CFTR conformational states associated with channel gating

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户：qwe007wc

【摘要】

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【作者】

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Feng Qian Xijiang Mao Lian Liu Chengbiao Lu

【机构】

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Laboratory of Neuronal Network and Brain Diseases Modulation,School of Medcine,Yangtze University,Ji

【出处】

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2016年国际生理学学术大会

【发表日期】

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2016年6期

【关键词】

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CFTR glycosylation open state

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　　Glycosylation is one of the most common protein post-translational modifications and plays an important role in protein folding,trafficking,and protein-protein interactions.CFTR chloride channel contains two evolutionary conserved N-glycosylation sites(N894 and N900)in the putative extracytoplasmic loop between the seventh and eighth transmembrane regions.

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Glycosylation affects CFTR conformational states associated with channel gating

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