Induction of Amyloid Fibrils by the Core Aggregation Sequences of TDP-43 C-Terminal Fragment

来源 :中国化学会第十届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户:donggua_dg
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  TAR DNA-Binding protein(TDP-43)is a major deposited protein in amyotrophic lateral sclerosis(ALS)and frontotemporal lobar degeneration with ubiquitin-positive inclusions(FTLD-U).
其他文献
  The overlapping substrate specificities within the family of MMP(Matrix Metalloproteinase)enzymes which were associated with tumorigenesis,adds the potentia
  Developing a nanoscaled theranostics with simple compositions to realize multiple diagnostic,therapy and targeting is highly desirable but remains a great c
  Ebola virus is an acute virus with terrible high mortality and violent infectivity,which can cause Ebola haemorrhaqic fever(EBHF)in humans and primates.
  The MarR type Zinc-specific transcriptional regulator ZitR contains two Zn(Ⅱ)-binding sites per dimeric subunit,with Site-1 being the primary Zn(Ⅱ)-sensin
  Bioorthogonal reaction pairs are playing more and more important role in chemical biology.Compared to traditional bioorthogonal coupling reaction,the biorth
  The uniform and extremely small-sized Fe3O4 nanoparticles decorated self-made graphene composites(G-Fe3O4)have been successfully prepared via a facile copre
  Bioorthogonal cleavage reaction has emerged as an attractive strategy for release the function of biomolecules,which enable us to study intracellular biomol
  揭示胚胎干细胞多能性的调节机制对促进其在细胞治疗和器官移植等再生医学领域的应用具有重要意义[1]。干细胞多能性维持和定向分化主要依赖于复杂而精细的转录调控网络
  Chimeric antigen receptor T-cell immunotherapy(Car-T)is an emerging but promising treatment to cancer.
  The"Switching-On" complexes,indolium derivatives bound with nuclear acids,were used as fluorescence probes to recognize the endonuclease and monitor the enz