以糖功能化金纳米粒子为探针的流感病毒受体特异性分析

来源 :2014年全国糖生物学学术会议 | 被引量 : 0次 | 上传用户：nickyhuang00

【摘要】

：

目的金纳米粒子的光学性质与其聚集-分散状态密切相关,当其由分散到聚集状态时,紫外-可见吸收(UV-vis)光谱发生明显改变,溶液颜色相应地由红色变为紫色.本研究将唾液酸寡糖修饰在金纳米颗粒上,合成了糖-金纳米粒子探针(gGNP),利用其与流感病毒血凝素蛋白(HA)相互作用时的聚集态变化,发展了一种简单、可视化地检测流感病毒受体特异性的新方法.

【作者】

：

未金花郑隆堂吕迅蒋兴宇高福杜昱光李学兵

【机构】

：

中科院病原微生物与免疫学重点实验室,中国科学院微生物研究所,北京100101;中国科学院过程工程研究所生化工程国家重点实验室糖生物工程课题组,北京100190

【出处】

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2014年全国糖生物学学术会议

【发表日期】

：

2014年8期

【关键词】

：

寡糖金纳米粒子流感病毒受体特异性唾液酸

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以糖功能化金纳米粒子为探针的流感病毒受体特异性分析

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