【摘 要】
：
Warfarin has been prescribed as a racemate for more than 40 years.However, the anticoagulant activity of its S enantiomer is about 5-8 times higher than of its R enantiomer and the enantiomers are met
【机 构】
：
Key Laboratory of the Ministry of Education for Advanced Catalysis Materials,Institute of Physical C
【出 处】
：
4th China - Australia Symposium for Materials Science(第4届中国-
论文部分内容阅读
Warfarin has been prescribed as a racemate for more than 40 years.However, the anticoagulant activity of its S enantiomer is about 5-8 times higher than of its R enantiomer and the enantiomers are metabolized by different pathways.Due to different anticoagulant activities and half-lives between the enantiomers, racemic warfarin often leads to many clinical consequences such as internal hemorrhages.Different approaches towards the synthesis of optically active warfarin have been reported.
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