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The primary constraints for efficient oral delivery of anticancer drugs include the barriers to drug absorption in gastrointestinal (GI) tract and efflux pump function of the multidrug transporter P-glycoprotein (P-gp) for anticancer drugs[1,2].To bypass P-gp drug efflux pumps and improve oral bioavailability of doxorubicin hydrochloride (DOX),multilayer micro-dispersing system was constructed by co-immobilization of DOX-loaded chitosan/carboxymethyl chitosan nanogels (DOX∶CS/CMCS-NGs),along with quercetin (Qu) in the core of multilayer sodium alginate beads (DOX∶NGs/Qu-M-ALG-Beads).