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  5. Elimination of donor CD47 attenuates T cell-and antibody-mediated cardiac allograft rejection in mic

Elimination of donor CD47 attenuates T cell-and antibody-mediated cardiac allograft rejection in mic

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：pkbaby
【摘 要】
：
Background: CD47 is a ubiquitously-expressed transmembrane glycoprotein that plays a complex role in regulation of cell survival and function.In cellular transplantation, donor CD47 was found to contr
【作 者】
：
Yuantao Wang Liguang Sun Hui Wang Yaowen Fu Yong-Guang Yang 
【机 构】
：
First Hospital of Jilin University, Changchun, China
【出 处】
：
中国免疫学会第九届全国免疫学学术大会
【发表日期】
：
2014年8期
【关键词】
：
CD47 heart transplantation humoral rejection mice 
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Background: CD47 is a ubiquitously-expressed transmembrane glycoprotein that plays a complex role in regulation of cell survival and function.In cellular transplantation, donor CD47 was found to contribute to repression of recipient innate immune cell activation and protection against phagocytic cell-mediated rejection.However, the role of CD47 in solid organ transplantation remains undetermined.
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