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To saudy whether there are differences between the early-onset and late-onset severe preeolamlusia in thr pathogenesis，to bring new highlights for clinical treatment of EOSP. Material and Methods Taking in newly diagnosed untreated early onset severe preeclampsia, late onset severe preeclampaia and the control groups in patients with elbow vein fasting blood 4-5Sml before delivery，using double antibody sandwich enzyme linked immunosorbent assay(ELISA) technique measured IFN-r,IL-10,IFN-r/IL-10 and sFlt-1 levels in the serum.