Objective Diffuse large B cell lymphoma(DLBCL)is the most common disease in non-Hodgkins lymphoma.Amplification on chromosome 18(chr18)frequently appears in DLBCL.The gene of TCF4(18q21.2),a multifunc
Objective Gastric cancer(GC)is the leading cause of cancer-related death worldwide due to its high morbidity and lack of effective treatments.Despite advances in surgical techniques,molecular targeted
Objective Hepatocellular carcinoma(HCC)is a common primary liver tumor which featured by high morbidity and mortality.Hepatocellular carcinoma also characterized by high metastatic capacity.The progno
Objective Wnt signaling,activated by secreted wnt ligands,is one of the fundamental mechanisms in development and homeostasis.As the most studied pathway,the canonical wnt signaling has been demonstra