Objective Ovarian metastasis from gastric cancer(Krukenberg tumor [KT])has no consensus treatment and the role of surgical treatment is still controversial.Identifying prognostic factors for KT could
Objective Objective: While anti-HER2 tyrosine kinase inhibitors(TKIs)have radically prolonged survival and improved the prognosis in HER2-positive breast cancer patients,resistance to these therapies
目的 The treatment of HER2-positive breast cancer remains a clinical challenge due to limited understanding of HER2-driving oncogenic signaling and frequent resistance to HER2-targeted therapy.Histone d
目的 脊索瘤是具有局部侵袭及转移能力的间叶细胞恶性骨肿瘤,起病隐匿,对放化疗不敏感.极高的局部复发率和致残率,导致脊索瘤患者常常预后较差.因此,如何提高脊索瘤患者生存率、减少肿瘤复发转移、探索肿瘤发病机制、寻找治疗新策略,是骨肿瘤学科急需解决的问题.近年来,越来越多的研究表明miRNA 在多种恶性肿瘤中起到癌基因和抑癌基因的作用,其表达水平的改变与肿瘤的发生、发展及预后密切相关.但在脊索瘤中miR
目的 Hepatocellular carcinoma(HCC)progression depends on cellular metabolic reprogramming as both direct and indirect consequence of oncogenic lesions.However,the underlying mechanisms are still underst
目的 恶性外周神经鞘瘤(MPNST)是雪旺氏细胞谱系起源的肉瘤，散发或与遗传性1 型神经纤维瘤病(NF1)相关.本研究旨在探讨高迁移率族蛋白A2(HMGA2)在NF1 型MPNST 进展中的作用及其潜在的分子机制.方法 免疫组织化学(IHC)用于检测MPNST 和神经纤维瘤患者样品中的HMGA2 表达情况.CCK-8、EdU、Tunel 和透射电子显微镜检查以揭示HMGA2 在体外和体内条件下对N
目的 癌高甲基化基因1(Hypermethylated in cancer 1,HIC1)是一种抑癌基因,同时也是一种转录抑制因子,它位于人类第17 号染色体短臂上。方法 该基因在很多实体肿瘤组织中存在表达沉默的现象。动物实验发现HIC1+/-小鼠能诱发多种自发性肿瘤,一些癌前病变组织(比如吸烟者的肺、大肠多发性息肉等组织)中也发现了HIC1 表达沉默,这些研究提示该基因可能与肿瘤的形成﹑发展和转
Objective Diffuse large B cell lymphoma(DLBCL)is the most common disease in non-Hodgkins lymphoma.Amplification on chromosome 18(chr18)frequently appears in DLBCL.The gene of TCF4(18q21.2),a multifunc
Objective Gastric cancer(GC)is the leading cause of cancer-related death worldwide due to its high morbidity and lack of effective treatments.Despite advances in surgical techniques,molecular targeted
目的 APOBEC3B 是炎症环境中诱导病毒及人体基因组损伤的重要分子,UNG 通过切除修复核酸突变对APOBEC3B 产生衡作用.本研究旨在明确遗传损伤-修复分子相关的遗传多态性对肝细胞癌、胆管癌和胆囊癌发生风险的影响,揭示炎症环境导致APOBEC-UNG 失衡并促进癌症进化的分子机制.方法 研究纳入1440 例健康观察对象、2000 例非癌症HBV 感染者、1200 例肝细胞癌(HCC)患者、