【摘 要】
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Liver microcirculation is unique in human body due to the complicated structure of sinusoidal nodes, in which multiple types of hepatic and/or hemapoietic cells interact with each other under blood fl
【机 构】
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Center of Biomechanics and Bioengineering and Key Laboratory of Microgravity (National Microgravity
【出 处】
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中国免疫学会第九届全国免疫学学术大会
论文部分内容阅读
Liver microcirculation is unique in human body due to the complicated structure of sinusoidal nodes, in which multiple types of hepatic and/or hemapoietic cells interact with each other under blood flow.Adhesion of flowing peripheral leukocytes to liver sinusoidal endothelial cells (LSECs) or Kupffer cells (KCs) is crucial in liver immune responses.While it is known that two b2 integrins LFA-1 and Mac-1 plays distinct functions in the most of organ-specific microcirculations,Mac-1 seems to be predominant in neutrophil (PMN) adhesion and crawling in localized inflammation while the role of LFA-1 is controversial in liver.
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