Design and synthesis of novel LSD1 inhibitors based on pyrimidine-thiourea hybrids

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：yys68738464

【摘要】

：

As the first identified histone demethylase,Lysine specific demethylase 1(LSD1)plays an important role in epigenetic regulation of gene activation and repression.

【作者】

：

Biao Hu Li-Ying Ma Bo Wang Lu-Ping Pang Wen-Jing Zong Yu-Pei Ma Qian-Lun Pu Chong-Yuan Fan Hong-Min Liu

【机构】

：

New Drug Research & Development Center,School of Pharmaceutical Sciences,Zhengzhou University,100 Ke

【出处】

：

2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

epigenetics LSD1 pyrimidine-thiourea hybrids

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　　As the first identified histone demethylase,Lysine specific demethylase 1(LSD1)plays an important role in epigenetic regulation of gene activation and repression.

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