Our group reported the synthesis of 6-substituted phenanthridines via radical reactions of 2-isocyanobiaryls1 and successfully developed cobalt-catalyzed reaction of 2-arylanilines with isocyanides to construct 6-aminophenanthridine derivatives,respectively.2 2-Aminoquinoline is a kind of organic compound,which has good biological and pharmaceutical activities.3 We envisioned that cobalt-catalyzed insertion reaction strategy might also be applied to promote the reaction of isocyanide with 2-vinylanilines.A series of 2-aminoquinolines are afforded by Co(acac)2 catalyzed isocyanide insertion with 2-vinylanilines under O2 atmosphere.This reaction not only uses low toxicity Co(acac)2 as the catalyst and oxygen as the oxidant,but also a new C(sp2)-C(sp2) bond and a new C(sp2)-N bond are constructed via single-step.