Sphingosine Kinase/Sphingosine 1-Phosphate (S1P)/S1P Receptor Axis is Involved in Liver Fibrosis-Ass

来源 :中国细胞生物学学会2013年全国学术大会 | 被引量 : 0次 | 上传用户:hei4477xx
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Background/Aims:Sphingosine kinase (SphK)/sphingosine 1-phosphate (S1P)/S 1P.receptor (S1PR) axis is involved in multiple biological processes,including liver fibrosis.
其他文献
Craniofacial malformations are common structural birth defects and usually associate with abnormal development of pharyngeal arches.Although some microRNAs (miRNAs) have been found to be implicated in
The tumor microenvironment could induce macrophages differentiation into Tumor-associated macrophages (TAM),which play an important role in the development of tumor inflammation.
VEGFa creates new vessels in embryonic development and organogenesis.Tumors produce a lot of VEGFa to adapt local vasculature for their progression and metastasis,thus anti-angiogenesis therapies,like
Primary cilia,which emanate from the cell surface,exhibit assembly and disassembly dynamics along the progression of cell cycle.However,the mechanism that links ciliary dynamics and cell cycle regulat
The most favored vascular access for hemodialysis of patients with chronic kidney disease(CKD) is an arteriovenous fistula (AVF).Failure of an AVF occurs mainly because of vascular stenosis which refl
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disease with a prevalence of 1∶500 to 1∶1000 in humans.
雄激素受体(Androgen Receptor,AR)是核受体超家族成员,以配体依赖方式介导基因转录,并招募一系列辅调节因子调控其转录,发挥其生物学功能.AR及其辅调节因子分别在前列腺癌中扮演着重要角色.
Protein kinase D (PKD) is a novel family of serine/threonine kinases and diacylglycerol(DAG) receptors and has been documented in a variety of cellular processes.Threeisoforms of PKD have been identif
Recombinant derived proteins are becoming increasingly important as therapeutic agents.HMGB1, composed of the A box, B box and C tail domains, is a critical proinflammatory cytokineinvolved in diverse
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine.In addition toits known receptor-mediated biological activities,MIF possesses a catalytic site of unknownfunction between sub