Intestinal mTOR regulates GLP-1 production in L cells

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户:laohe5201314
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Aims/hypothesis: Glucagon-like peptide(GLP-1),an intestinal incretin produced in L-cells through proglucagon processing,is released in response to meal intake.The intracellular mechanism by which L cells sense the organism energy level to coordinate the production of GLP-1 remains unclear.
其他文献
Paracellular pathway via tight junction is an important route for materials transport.However,whether muscarinic acetylcholine receptors(mAChRs)regulate tight junction proteins of submandibular gland,
Kv10.1(hEAG)is a member of the large family of voltage-gated potassium channels.Functional channels are homotetramers,with each monomer comprised of six transmembrane segments.hEAG channels are distin
会议
Introduction: Chronic exposure to noise might induce liver damage including increased oxidative stress in hepatocyte,liver tissue loose and edema,vascular congestion and inflammatory cell infiltration
Ghrelin,a 28-amino acid hormone produced mainly by theX/A-like endocrine cells in gastric mucosa,is critical for the regulation of energy metabolismand inflammation.It is currently unknown whether ghr
Hyperhomocysteinemia(HHcy)is an independent risk factor for atherosclerosis with high secretion of interleukin-17A(IL-17A)in T lymphocytes.However,the mechanisms underlying the regulation of IL-17A ar
The farnesoid X receptor(FXR)is a ligand-activated transcription factor belonging to the nuclear receptor superfamily.FXR is mainly expressed in liver and small intestine,where it plays an important r
会议
Endoplasmic reticulum(ER)stress has been implicated in some types of glomerular and tubular disorders.The objectives of this study were to elucidate the role of ER stress in lithium-induced nephrogeni
Alcoholic fatty liver disease(AFLD)is the leading cause of chronic liver disease worldwide.An early response of the liver to alcohol ingestion is development of steatosis,which may further progress to
Introduction: High fat diet treatment as little as 3 days can induce fatty liver,insulin resistance and adipose inflammation.ω-3 PUFAs and their metabolites mediate protective effects on several metab
Hyperhomocysteinemia(HHcy)is associated with liver diseases such as fatty liver and hepatic fibrosis; however,the underlying mechanism is still largely unknown.The current study aimed to explore the s
会议