干扰素调节因子4(IRF4)通过转录调控细胞分化核心转录因子及分泌型细胞因子表达,从而介导体内多种天然免疫细胞如树突状细胞和巨噬细胞,辅助性T细胞如Th2, Th9,Th17,和调节性T细胞如FOXP3+Treg等不同细胞亚型的分化与功能。目前,IRF4在不同免疫细胞亚群中是如何行使其特定转录功能的分子机制尚不清楚。我们发现在TCR刺激条件下,CD4+T细胞中IRF4蛋白K123位点发生单甲基化,
Lysophosphatidic acid (LPA) is an important phospholipid mediator in inflammation and immunity.However, the mechanism of LPA regulation during inflammatory response is largely unknown.Autotaxin (ATX)
Being a first-line defense, the epidermis is in constant confrontation against pathological or mechanical insults that disrupt the epidermal architecture.
Osteopontin (OPN) is a multifunctional protein involved in both innate immunity and adaptive immunity.However, the function of OPN, especially the intracellular form OPN (iOPN) on antiviral immune res
病毒的感染与致病是病毒因素和宿主因素相互作用的结果,既有病毒为逃避宿主防御机制而进行的改变,也有宿主为清除病毒而调动固有免疫体系迅速产生效应分子和免疫效应,构建机体抵御病毒入侵的生物防线.IFN调节因子(interferon regulation factor,IRF)家族在IFN的诱导表达中起着重要的调节作用,近来研究表明IRF-7是诱导IFN表达的最主要的调节因子.
Jawless vertebrates represented by lampreys and hagfish use variable lymphocyte receptors (VLRs) as antigen receptors to mount adaptive immune responses.Lampreys have two populations of lymphocytes ex
Rice blast resistance by Resistance (R) genes for elicitor-triggered immunity (ETI) is race specific and prone to break down.
Nuclear factor of kappa B (NF-κB) is a stimuli-activated transcription factor, regulates the expression of a diverse array of genes.
肝血窦是肝脏微循环的重要组成部分，具有复杂的细胞组成和特殊的血流剪切环境。血液中的白细胞与肝血窦内皮细胞和枯否氏细胞等的相互作用，对于肝内的天然免疫和适应性免疫应答非常重要。不同的炎症情况下，血液中的中性粒细胞在肝血窦内粘附，爬行，跨膜迁移，募集到炎症部位，提供宿主防御并清除侵入物，或者诱发炎症相关的组织损伤。
B-cell activating factor (BAFF) is involved in not only physiology of normal B cells, but also pathophysiology of aggressive B cells related to malignant and autoimmune diseases.