【摘 要】
：
Macrophages are found in majority of malignant tumors.The object of this study is to evaluate the effect of mmumiR-222 on infiltration of macrophages to breast tumor andstudy the mechanisms ofmmu-miR-
【机 构】
：
State Key Laboratory of Medical Molecular Biology, School of Basic Medicine, Peking Union Medical Co
【出 处】
：
中国免疫学会第九届全国免疫学学术大会
论文部分内容阅读
Macrophages are found in majority of malignant tumors.The object of this study is to evaluate the effect of mmumiR-222 on infiltration of macrophages to breast tumor andstudy the mechanisms ofmmu-miR-222 in TAM.Method: We detected the expression level of miR-222, miR-221 and miR-31 in TAM and macrophage from normal PBMC (Peripheral blood mononuclear cells) using real time-PCR.We further verified them in mouse TAM derived from tumor formed by 4T1 cells and macrophages fromthe abdominal cavity of mouse.
其他文献
Background : Pancreatic cancer is an aggressive disease with a high rate of cell metastasis.Regenerating islet-derived protein 3-alpha (REG3A), a secreted pancreas protein and cell proliferation facto
Mitochondrial GTPase mitofusin-2 gene (Mfn2) is a novel gene characterized as a cell proliferation inhibitor.Recently, Mfn2 has been reported to have a potential role in regulating cell proliferation,
Stem cell-like cancer cells, a minor population in tumour mass acting as the source of tumour recurrence and metastasis, are extraordinarily resistant to chemotherapeutic drugs, leading to a major cli
背景:胃癌是全球排名第四的恶性肿瘤,免疫抑制微环境的建立与持续性存在是导致胃癌发生发展的重要因素,我们前期的研究发现胃癌中CD8+T细胞功能受到抑制并介导了胃癌的不断进展和预后不良,而作为另一重要的抗肿瘤免疫细胞即NK细胞在胃癌中的功能和调控并不清楚.目的:研究NK细胞在胃癌中的功能变化及其调控,进一步阐明胃癌免疫逃逸的机制.方法:流式细胞技术检测NK细胞在胃癌患者不同组织中的分布、表型及功能,流
Background: In spite of its reputation as a T cell regulator, little is known about the PD-L 1 acting as a tumor marker.Method: Here, the relationship between cell differentiation and changes in the s
To investigate the inhibitory effect of epirubicin (EPI)-loaded lipid microbubbles (MBs) bound with anti-ABCG2 monoclonal antibody (EPI-MBs+mAb) combined with therapeutic ultrasound on multiple myelom
Highly pathogenic avian influenza A virus H5N1 continues to spread among poultry and has frequently broken the species barrier to humans, calling for effective vaccines and therapeutics.In this work,
Background : Endogenous antigen encoded by conventional naked DNA was processed by antigen-presenting cells (APCs) and only presented to CD8+ T cell through forming peptide/MHC Ⅰ (major histocompatibi
目的:通过检测miR-155在NK/T细胞淋巴瘤患者外周血及人NK/T细胞淋巴瘤细胞株SNK-6细胞中的表达,探索其与NK/T细胞淋巴瘤临床特征的相关性及其可能的作用机制,以期寻找NK/T细胞淋巴瘤新的肿瘤标记物及预后预测指标.方法:1.研究对象:患者血液标本来自于2013年～2014年3月间,就诊于河北医科大学第四医院血液科的NK/T细胞淋巴瘤患者.所有患者均签署知情同意书.2.人NK/T细胞淋
研究背景:E盒锌指结合蛋白1 (Zinc finger E-box binding homeobox 1,ZEB1)在多种肿瘤中高表达,在某些肿瘤中可以作为预后判断的标志分子.然而,ZEB1在结肠癌中的临床意义尚不明确.目的:在结肠癌组织样本中检测ZEB1的表达水平,分析其与临床病理特征的相关性;在结肠癌HCT116细胞中下调ZEB1的表达,分析其对细胞生物学功能的影响.方法:用免疫组织化学的方法