【摘 要】
：
In vivo optical imaging is emerging as an important technique in medical imaging, and the development of safe and effective fluorescence-based probes has attracted many attentions.Mesoporous silica na
【机 构】
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National Engineering Research Center for Biomaterials,Sichuan University,Chengdu 610064,China
【出 处】
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International Conference on Nanoscience & Technology,China 2
论文部分内容阅读
In vivo optical imaging is emerging as an important technique in medical imaging, and the development of safe and effective fluorescence-based probes has attracted many attentions.Mesoporous silica nanoparticals (MSNs) and dendrimers have showed promising platform as imaging probes [1-2].In this study,we report the fabrication and application of mesoporous silica-peptide dendrimers nanohybrid based nanoprobe that can facilitate near-infrared (NIR) optical imaging.The nanohybrid was prepared by surface modification of MSNs via click reaction of azido-MSNs with alkynyl peptide dendrimer.After labeling with the near-infrared dye Cy5.5,the nanoprobe with diameters of 60 nm was obtained and characterized well by TEM, SEM, TGA, nitrogen adsorption-desorption isotherms.
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