Aims With the development and wide application of gastrointestinal endoscopy technology, endoscopic resection of the polyps in digestive tract is the first-line treatment of gastrointestinal polyps.However, polyps located at duodenal bulb near to pyloms cannot be visualized completely by forward endoscopic view, unless the retroflexion view technique is performed.Endoscopic resection of this type of polyps by using retroflexion technique in duodenum is difficult, due to the operation space is limited and narrow.We report here a case of Endoscopic resection of a polyp located at duodenal bulb near to pylorns with retroflexion technique.