【摘 要】
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Objectives Colorectal cancer (CRC) remains the third most popular cancer in US.CRC biopsy usually shows substantially increased angiogenesis, which is promoted by a number of pro-angiogenic growth fac
【机 构】
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Interdisciplinary Division of Biomedical Engineering,The Hong Kong Polytechnic University,Hong Kong
【出 处】
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第三届全国暨国际超声分子影像及生物效应和治疗学术会议
论文部分内容阅读
Objectives Colorectal cancer (CRC) remains the third most popular cancer in US.CRC biopsy usually shows substantially increased angiogenesis, which is promoted by a number of pro-angiogenic growth factors.Among all these factors, the expression of endoglin has been remarkably up-regulated on actively proliferating endothelial cells of neo-vasculature.Endoglin has been an independent clinical pathological target for the tumor aggressiveness assessment.In this study,we developed endoglin-targeted microbubbles (MBs), and employed targeted microbubbles enhanced ultrasound (US) imaging to assess the endoglin expression levels in neo-vasculature for non-invasive assessment of colorectal tumor angiogenesis.
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