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Objective:The study was designed to investigate the protective effect of resveratrol on chondrocytes in osteoarthritis and clarify its mechanism. Methods:Forty male Sprague-Dawley rats (3-month-old, 385±25g) were used in this study. These rats were randomly divided into four groups (10 rats per group). Group 1 is the sham operation group, group 2 is the blank control group, group 3 is the lowdose group, and group 4 is the high-dose group. Anterior cruciate ligament transaction (ACLT) was used to establish the osteoarthritis model.