Introduction:The application of activated charcoal hemoperfusion accelerated the removal of PQ from the blood.However, there are no reports focus on the effect of activated charcoal hemoperfusion on renal function and PQ elimination of kidney.Materials and Methods:Nineteen PQ poisoning patients were observed respectively.Plasma and urine samples were collected from nineteen paraquat poisoning patients who received activated charcoal hemoperfusion therapy after admission.Plasma and urine paraquat concentration were assayed by a gas chromatography method.The relationship between plasma paraquat concentration and urine paraquat concentration of the patients was analyzed.Results:Among the nineteen patients, seven patients died, twelve patients survived.N6n-oliguric renal failure occurred in all seven death patients.Among the twelve survival patients, ten patients had normal renal function, two developed non-oliguric renal failure.There was a linear relationship between plasma and urine paraquat concentration before and during activated charcoal hemoperfusion was performed.The equation parameters together with the correlation coefficient were as follows at admission:Y =0.5820 + 1.7348X (R2=0.678, F=35.768, P<0.0001).The equation parameters together with the correlation coefficient were as follows during activated charcoal hemoperfusion was performed:Y =0.6827 + 1.2649 X (R2=0.626, F=50.308, P<0.0001).Conclusions:The toxicokinetic of the kidney on PQ was just related to plasma PQ concentration.Activated charcoal hemoperfusion has little effect on avoiding acute kidney injury in severe PQ-poisoned patients.