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目的：探讨卡维地洛早期干预抑制急性心梗(A-MI)后大鼠心肌纤维化的作用机制。方法：以手术结扎左冠脉前降支(LAD)法制备大鼠AMI模型。结论：中、高剂量卡维地洛干预能降低AMl后大鼠心肌内促炎因子MIF表达，从而抑制AMI后心肌纤维化，改善心功能。
卡维地洛降低促炎因子MIF表达抑制AMI后大鼠心肌纤维化
【摘 要】
：
目的：探讨卡维地洛早期干预抑制急性心梗(A-MI)后大鼠心肌纤维化的作用机制。方法：以手术结扎左冠脉前降支(LAD)法制备大鼠AMI模型。结论：中、高剂量卡维地洛干预能降低AMl后大鼠心肌内促炎因子MIF表达，从而抑制AMI后心肌纤维化，改善心功能。
【机 构】
：
广东省医学科学院;广东省人民医院医学研究中心;广东省心血管病研究所,广州 510080 广东省医学
【出 处】
：
第14届中国南方国际心血管病学术会议
【发表日期】
：
2012年5期
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