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Berberine, an isoquinoline plant alkaloid, is known to have anti-tumor effects on many kinds of carcinoma cells mainly through inhibition of cell proliferation,induction of apoptosis,and cell cycle arrest.However,mechanisms underlying the role of berberine in tumor progression remain to be elucidated.Here we investigated the possible molecular mechanisms of berberine-induced cell death in human hepatocarcinoma cell (HCC) lines HepG2 and SMMC7721.