【摘 要】
：
Chronic infection with hepatitis B virus (HBV) is associated with the majority ofhepatocellular carcinoma (HCC).The diagnosis of HCC is usually made in the
【机 构】
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NobelPrizeLaureateinPhysiologyorMedicine,1976
【出 处】
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2005 World DNA and Genome Day(2005中国(大连)国际DNA和基因组节大会)
论文部分内容阅读
Chronic infection with hepatitis B virus (HBV) is associated with the majority ofhepatocellular carcinoma (HCC).The diagnosis of HCC is usually made in the late stages of the disease,when treatment options are limited and prognosis is poor.We therefore have developed a method of glycoproteomic analysis in an attempt to discover serum markers that can assist in the early detection of HBV-induced liver cancer.Briefly,a comparative method for analysis of oligosaccharides released from serum glycoproteins and for recovery and identification of proteins with aberrant glycosylation,as a function of cancer diagnosis,is described.The model we have used is the woodchuck (Marmota monax),which shares similarities in the glycosylation pattern associated with liver proteins in human HCC.In this report,we show that woodchucks diagnosed with HCC have dramatically higher levels of serum-associated core-1,6-1inked fucose,as compared with woodchucks without a diagnosis of HCC.
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