顺磁镧系离子研究蛋白质动态与相互作用方法及进展

来源 :The First Asian Conference on Porphyrins, Phthalocyanines an | 被引量 : 0次 | 上传用户:b903630080
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  顺磁共振包括顺磁核磁和电子自旋共振在化学生物学和结构生物学中发挥着重要作用。[1]在生物大分子上定点标记顺磁镧系离子,借助于高灵敏的顺磁效应能在一定程度上可以提高核磁共振检测限度并在结构生物学中发挥着重要作用。顺磁核磁共振和电子自旋共振都是借助顺磁物质的磁性研究原子核和电子间的波谱学性质,通过核磁共振发展和优化的高性能顺磁镧系离子螯合探针可以窄化双电子自旋共振(DEER)测定的距离分布,提高DEER测量中的分辨率。
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