【摘 要】
：
Aim To investigate the effect of hydrogenrich saline on arterial thrombosis in sinoaortic denervatted(SAD) rats.Methods Rats were divided randomly into Sham group, SAD group, SAD + hydrogenrich saline
【机 构】
：
School of Pharmaceutical Science,Taishan Medical University,Taian 271000,China;Department of Pharmac
论文部分内容阅读
Aim To investigate the effect of hydrogenrich saline on arterial thrombosis in sinoaortic denervatted(SAD) rats.Methods Rats were divided randomly into Sham group, SAD group, SAD + hydrogenrich saline(5 mL · kg1 · d1) group and SAD + hydrogenrich saline (10 mL · kg1 · d1) group.Four weeks after Sham or SAD operation, rats were given intraperitoneally normal saline or hydrogenrich saline for 4 weeks.Carotid artery thrombosis was induced by 30% ferric chloride.Time till occlusion was measured by Laser Doppler Flowmetry.Results When compared with the Sham group, time till occlusion was significantly shorter in SAD group.Moreover, platelet aggregation, platelet adhesion to collagen and the level of ROS and malondialdehyde (MDA) in plasma and Ca2 + in platelets were significantly raised.The level of NO and SOD in plasma and NO in platelet were significantly reduced.When compared with the SAD group, time till occlusion in hydrogenrich saline group group was significantly prolonged.Platelet aggregation, adhesion, the level of ROS, MDA and Ca2 + were significantly reduced, whereas the level of NO and SOD in plasma and NO in platelets were significantly higher.Conclusion Hydrogenrich saline might improve arterial thrombosis in SAD rats through inhibition of platelet activation and oxidative stress.
其他文献
Aim Brain inflammation plays an important role in the pathophysiology of many psychiatric and neurological diseases.Angiotensin Ⅱ type 1 receptor blockers (ARBs) ameliorate brain inflammation and redu
Aim YL0919 is permitted by SFDA for clinical trial recendy as a new drug for depression.Whether YL0919 is a fastonset antidepressant and the possible mechanism related to mTOR pathway will be investig
Background and Ain Druginduced sensitization in the mesocorticolimbic systems has been thought to play an important role in certain aspects of drug addiction, including the important function of druga
The sensitive tyrosine hydroxylasegreen fluorescent protein (THGFP) transgenic zebrafish was originally developed and applied as a biosensor to assessments of the effects of addict drugs in our previo
Aim Some indirect evidences indicate a possible correlation between oxidative stress and motion sickness.The aim of this research was to investigate whether oxidative stress contributing to motion sic
Our recent study demonstrated that pinocembrin (PB), the most abundant flavonoid in propolis, has neuroprotective effect against 1methyl4phenylpyridinium (MPP +)induced SHSY5Y neurotoxicity.However,th
Aim Posttraumatic nightmares are a core component of posttraumatic stress disorder (PTSD) and mechanistically linked to the development and maintenance of this disorder, but little is known about thei
Aim It has been widely accepted that autophagy plays a key role in some human diseases such as Parkinson s disease (PD).UNC5 llike kinasesl (ULK1) has been widely reported to initiate autophagy via it
Aim Fragile X mental retardation protein (FMRP) is an RNAbinding protein important for the control of translation and synaptic function.The mutation or silencing of FMRP causes Fragile X syndrome (FXS
Aim Leptin, a 16 ku hormone from the ob gene, has been identified as an important protein involved obesity.As a chronic metabolic disorder, Obesity is associated with a high risk of developing cardiov