Targeting Plasminogen Activator Inhibitor-1 to Prevent Vascular Disease

来源 :微循环国际研讨会暨第十三届全国中西医结合微循环学术会议(International Conference for Mic | 被引量 : 0次 | 上传用户：hongtu200909

【摘要】

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【作者】

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Jian-Bo Wu

【机构】

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Drug Discovery Research Center,Luzhou Medical College,Luzhou,Sichuan,China

【出处】

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微循环国际研讨会暨第十三届全国中西医结合微循环学术会议(International Conference for Mic

【发表日期】

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2013年2期

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Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of urinary-type and tissue-type plasminogen activators and a key regulator of fibrinolysis.PAI-1 also regulates the function of vascular cells, including vascular smooth muscle cells (VSMCs).PAI-1 inhibits VSMC migration by inhibiting plasmin formation and preventing degradation of extracellular matrix (ECM) and elastic laminae.PAI-1 binds vitronectin (VN), an ECM protein whose PAI-1 binding site overlaps with those on VN for integrin αvβ3 and u-PA receptor (uPAR), cell surface proteins that control VSMC migration.

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Targeting Plasminogen Activator Inhibitor-1 to Prevent Vascular Disease

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