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  5. Ghrelin Receptor Agonist, GHRP-6, Produces Antinociceptive Effects at the Supraspinal Level via the

Ghrelin Receptor Agonist, GHRP-6, Produces Antinociceptive Effects at the Supraspinal Level via the

来源 :第十三届中国国际多肽大会 | 被引量 : 0次 | 上传用户：sykjzhb
【摘 要】
：
GHRP-6 is a synthetic agonist of ghrelin receptor.GHRP-6 has similar physiological functions with ghrelin[1-2].In our previous study,ghrelin(i.c.v.)could induce analgesic effect through an interaction
【作 者】
：
Jie Wei Ping Zeng Fu-Yan Liu 
【机 构】
：
Department of Physiology,Medical College of Nanchang University,Bayi Road 461,Nanchang,Jiangxi,33000
【出 处】
：
第十三届中国国际多肽大会
【发表日期】
：
2014年5期
【关键词】
：
GHRP-6 Growth hormone secretagogue receptor 1 alpha (GHS-R1a) Opioid receptor An 
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　　GHRP-6 is a synthetic agonist of ghrelin receptor.GHRP-6 has similar physiological functions with ghrelin[1-2].In our previous study,ghrelin(i.c.v.)could induce analgesic effect through an interaction with GHS-R1α and with the central opioid system in the acute pain in mice[3].To date,the function of GHRP-6 in pain processing was not understood.Therefore the aim of this study was to investigate the effects of GHRP-6 on pain modulation at supraspinal level in mice using the tail immersion test.Intracerebroventricular(i.c.v.)administration of GHRP-6(0.1,0.3,1,3 and 10 nmol/L)produced a concentration-and time-related antinociceptive effect.This effect could be fully antagonized by GHS-R1α antagonist [D-Lys3]-GHRP-6,indicating that the analgesic effect induced by GHRP-6 is mediated through the activation of GHS-R1α.
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