Bombyx mori is an economically important insect, also a mode of Lepidoptera insect.In basic metabolism and genetic aspects, the silkworm has a lot of similarities with humans.Using silkrworm as a model animal for drug screening and evaluation has a number of advantages.Silkworm as model animals already plays a role in many aspects, such as human physiology, disease, genetic research and developing new drugs.Silkworm as innate immune activation mode, bacterial infection mode and liver disease mode in the field of medical research is of great significance.Isoniazid (INH) as the irreplaceable clinical first-line anti-TB drugs have been plagued by current medical damage effect.