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Pyruvate dehydrogenase (PDH) is the multi-enzyme complex of mitochondrion.Its catalysis is of great importance in the process of energy metabolism.PDH catalyzes the decarboxylation of pyruvic acid to produce acetyl coenzyme A.And acetyl coenzyme A serves as the primary raw material to bring the glucose into the aerobic oxidation of tricarboxylic acid cycle.Due to insufficiency of PDH, human body suffers from lactic acidosis and atelencephalia.