2. 您的位置
3. 首页
4. 会议论文
5. A Dimethyl-Labeling-Based Strategy for Site-Specifically Quantitative Chemical Proteomic

A Dimethyl-Labeling-Based Strategy for Site-Specifically Quantitative Chemical Proteomic

来源 :第十一届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户：zl168

【摘 要】

：

Activity-based protein profiling(ABPP)has emerged as a powerful functional chemoproteomic strategy which enables global profiling of proteome reactivity towards bioactive small molecules in complex bi

【作 者】

：

Fan Yang Chu Wang 

【机 构】

：

College of Chemistry and Molecular Engineering,Peking University,Beijing 100871

【出 处】

：

第十一届全国化学生物学学术会议

【发表日期】

：

2019年3期

【关键词】

：

Quantitative chemical proteomics dimethyl labeling ferroptosis 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Activity-based protein profiling(ABPP)has emerged as a powerful functional chemoproteomic strategy which enables global profiling of proteome reactivity towards bioactive small molecules in complex biological and/or pathological processes.

其他文献

Coevolution-based prediction of metal binding sites in proteomes by machine learning

Metal ions play various important biological functions in proteins including structural maintenance,molecular recognition and catalysis.

会议

metalloproteomemetal-binding sitescoevolutionmachine learning

DNA折纸框架引导的三维组装体的构建

利用自下而上的构建方法将纳米尺度的基本单元组装成微米级的三维结构一直是超分子自组装领域的研究热点,DNA 纳米技术的发展为这一研究打开了新的突破口。

会议

DNA纳米技术、八面体DNA折纸框架超分子自组装纳米粒子

Direct sequencing of 2'-deoxy-2'-fluoroarabinonucleic acid(FANA)using nanoporeinduced phas

2-deoxy-2-fluoroarabinonucleic acid(FANA),which is one type of xeno-nucleic acid(XNA),has been intensively studied in molecular medicine and synthetic biology because of its superior gene-silencing an

会议

Unnatural nucleic acidNanopore sequencing

基于细胞表面工程的通用型红细胞制备

临床输血时，当供血者与受血者的血型不匹配时，就会发生溶血性输血反应，严重者会导致受血者死亡。虽然为了满足临床输血的需求，建立了输血库，但用血量逐年增加，尤其是稀有血型更是供不应求。

会议

红细胞多巴胺抗体掩蔽输血

Cytosolic delivery of CRISPR/Cas9 ribonucleoproteins for genome editing using chitosan-coated red fl

Though plenty of viral and non-viral methods have been rapidly developed for the delivery of the CRISPR/Cas9 system,the direct delivery of Cas9 ribonucleoproteins(RNPs)into the nucleus for genome edit

会议

CRISPR/Cas9RFP@CSHDRgene editing

NAMI-A Preferentially Reacts with Sp1 protein:Understanding Anti-metastasis Effect of the Drug

Zinc finger protein Sp1 is associated with tumor development,growth and metastasis.

会议

NAMI-Azinc finger proteinSp1glutathione

Exploit the Genome Reassortment as a Weapon to Against Influenza Virus Infection

Based on the segmentation of influenza virus genome,it is possible for two distinct strains exchange intact genome segments when they co-infect one cell,termed reassortment.

会议

Influenza A virusReassormentPremature termination codons (PTCs)

Co-expression of Cas9 and single guided RNAs in Escherichia coli fordirect production of Cas9 RNP

CRISPR/Cas9 ribonucleoprotein(RNP)complexes are promising biological tools with diverse biomedical applications.However,to date there are no efficient methods that can produce these proteins at large

会议

CRISPR/Cas9ribonucleoproteinCL7/IM7

理性设计辅助的蛋白质功能检测与调控

对蛋白质的活性位点进行检测与调控是对蛋白进行功能研究以及对蛋白相互网络进行调控的重要方法。传统的基于活性的蛋白质组分析(Activity-basedprotein profiling,ABPP)技术可以实现对一类功能位点活性的检测；而我们刚开发的CAGE-Prox 技术[1]可以实现对单一蛋白活性位点进行从“关”到“开”的特异性操控。

会议

理性设计共价结合探针

等离子激元分子结中铜离子螯合作用的动态探测

铜(Cu)是一种健康成长和正常生理机能所必需的的主要微量元素，人体中铜含量是关节炎、糖尿病、心脑血管病、癌症等多种疾病症状的重要指标，而人体内所有可计数的Cu 都是以Cu 的络合物的形式存在。

会议

Cu2+螯合作用SERS动态拉曼电压调控