【摘 要】
：
Therapeutic hypothermia is a promising strategy for acute cerebral ischemia via physical or pharmacological methods.In this study,we found that PD149163 cou
【机 构】
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Neuroprotective Drug Discovery Center,Jiangsu Key Laboratory of Neurodegeneration,Department of Phar
【出 处】
：
中国药理学会北美分会药理学学术大会
论文部分内容阅读
Therapeutic hypothermia is a promising strategy for acute cerebral ischemia via physical or pharmacological methods.In this study,we found that PD149163 could prevent neuronal damage,and inhibit proliferation and activation of astrocytes induced by ischemia,without altering local cerebral blood flow.Simultaneously,we observed PD149163 down-regulated caspase-3 and Bax,but elevated Bcl-2,indicating apoptosis was ameliorated.PD149163 could increase p62 expression,decrease the ratio of LC3-II to LC3-I and Beclin expression,suggesting autophagy was inhibited.
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