【摘 要】
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Protein kinase D (PKD) is a family of novel diacylglycerol/phorbol ester targets that regulates many important cellular functions including cell growth and
【机 构】
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Department of Pharmacology and Chemical Biology University of Pittsburgh School of Medicine USA
【出 处】
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BIT Life Sciences' 1st Annual World Cancer Congess-2008(
论文部分内容阅读
Protein kinase D (PKD) is a family of novel diacylglycerol/phorbol ester targets that regulates many important cellular functions including cell growth and survival.We now provide experimental evidence to indicate that PKD3 contributes to prostate cancer cell growth and survival.Expression of PKD3 as well as PKD1 was significantly higher in human prostate tumors compared with normal tissues as revealed by immunohistochemistry.Moreover, PKD3 exhibited a marked increase in nuclear localization in tumor tissues, which correlated with tumor grade.Isoforms of PKD were differentially expressed and localized between normal and human prostate cancer cells.
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