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目的 Notchsignalingplayavitalroleincommunicationbetweeninnateimmunityandadaptiveimmunity.Here,weinvestigatedtheexpressionofNotchligandDelta1inalveolarmacrophages(AMs)andreceptorNotch1onsplenicTcellsinchronicobstructivepulmonarydisease(COPD)associatedwithPM2.5exposure.MeanwhileTh17andTregcellsubgroupdifferentiationweredetected.