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Objectives To study the influence of chronic hypoxia during pregnancy on cardiovascular renin angiotensin system procedural control in male offspring rats.Methods Estabilished chronic hypoxia model in different periods of pregnancy.36 pregnant rats were randomly assigned to six groups as follow: hypoxia groups started in pregnancy on the 3rd day (G1), 6th day (G2), 9th day (G3), 12th day (G4), 15th day (GS) and control group (G0).