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Objectives Hypoxia could induce pulmonary arterial smooth muscle cells (PASMCs) proliferation via hydrogen peroxide (H2O2)-induced oxidative stress.Our previous research had demonstrated that vascular peroxidase 1 (VPO1) could utilise hydrogen peroxide generated from co-expressed NADPH oxidase to produce hypochlorous acid (HOCl) and catalyse peroxidative reactions.