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目的 亮氨酸重复区免疫球蛋白样蛋白1(Leucine-rich repeats and immunoglobulin-likedomains1,LRIG1)是在1996 年作为亮氨酸重复区/免疫球蛋白样的跨膜糖蛋白被发现的,用维甲酸处理老鼠胶质瘤细胞系时LRIG1 发生上调(cDNA cloning of a novel membrane glycoproteinthat is expressed specifically in glial cells in the mouse brain.LIG-1,a proteinwith leucine-rich repeats and immunoglobulin-like domains).