A novel PKCε-Smad2/3 signaling contributes to Warburg effect by up-regulating glycolytic gene expres

来源 :中国细胞生物学学会2015年全国学术大会 | 被引量 : 0次 | 上传用户：fpkneo

【摘要】

：

【作者】

：

Wanfu Xu Songyu Li Lin Zhang Yaodong Wang Zhe Xing Shao Li Fangyin Zeng Fan Deng

【机构】

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Department of Cell Biology, School of Basic Medical Sciences,Southern Medical University, Guangzhou,

【出处】

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中国细胞生物学学会2015年全国学术大会

【发表日期】

：

2015年4期

【关键词】

：

Prostate cancer glycolysis Smad2/3 PKCε

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　　Cancer cells use aerobic glycolysis preferentially for energy provision, and this metabolic change is critical for tumor growth.Smad2 and Smad3 are components of the transforming growth factor β (TGF-β) signaling play an important role in tumorigenesis and progression in cancer.However, whether Smads regulate tumor growth through aerobic glycolysis remain unclear.

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A novel PKCε-Smad2/3 signaling contributes to Warburg effect by up-regulating glycolytic gene expres

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