Objective Quality of life level and anxiety of parents whose children suffered from congenital heart disease was investigated and the results will provide reference for clinical work.Methods We used SF-36 and SAS to assess quality of life,and anxiety level.Results The scores of physiological function,physiological function,energy,social function,emotional function,mental health were significantly lower than the domestic norm,and the difference was statistically significant.The average score of SAS was(40.80+8.50)points higher than domestic norm(37.23-12.59),statistically significant difference(P < 0.01).Each dimension score of SF-36 had significantly negative correlation with SAS.Conclusion The quality of life of parents of children with congenital heart disease was low,some parents had existential anxiety symptoms.Nursing staff should strengthen the psychological nursing,do a good job in health education,improve the anxiety symptoms,and improve the quality of life.