Microarray-Based Analyses in Monocytes of Chinese Uygur Patients with Parkinson's disease and C

来源 :2015中国老年医学和老年健康产业大会 | 被引量 : 0次 | 上传用户:ynhappyma
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OBJECTIVE: The study aimed to identify potential biomarkers associated with Chinese Uygur Parkinsons disease (PD) with cognitive impairment (PD-CI) in peripheral monocytes.METHODS: We applied gene expression profiling to the study of peripheral monocytes from 3 Chinese Uygur patients with PD-CI and 3 healthy control subjects.Healthy control subjects were matched for age and gender with PD-CI subjects, RNA was extracted from the monocytes samples and the gene expressions were measured using the Illumina HumanHT-12 v4.0 Expression BeadChip, according to the screening criteria of Ratio≥2 and Ratio≤-2.At last, QuantiFast SYBR Green PCR (qRT-PCR) test was performed on samples collected from 31 PD-CI subjects and 35 controls to verify the microarray results.
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